Infection, pathology and interferon treatment of the SARS-CoV-2 Omicron BA.1 variant in juvenile, adult and aged Syrian hamstersArticle Published on 2022-12-012023-07-10 Journal: Cellular and Molecular Immunology [Category] COVID19(2023년), [키워드] innate immune response interferon treatment Lung pathology SARS-CoV-2 Omicron. [DOI] 10.1038/s41423-022-00923-9 PMC 바로가기
Updated vaccine protects against SARS-CoV-2 variants including Omicron (B.1.1.529) and prevents transmission in hamstersArticle Published on 2022-11-042022-11-15 Journal: Nature Communications [Category] SARS, 변종, 진단, 치료기술, [키워드] Antigen B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 Beta block Community COVID-19 vaccine current Delta delta variant detectable Efficacy eliminating expressed Fever Gamma hamster immunization Lineage Lung pathology maintain Neutralizing antibody response omicron P.1 pandemic predominant Prevent PROTECT SARS-CoV-2 strains SARS-CoV-2 variant sequence Spread titre Transmission Vaccine variants variants of concern vectored vaccine virus VoC VOCs [DOI] 10.1038/s41467-022-34439-7 PMC 바로가기
Intrinsic host susceptibility among multiple species to intranasal SARS-CoV-2 identifies diverse virological, biodistribution and pathological outcomesArticle Published on 2022-11-042022-11-15 Journal: Scientific Reports [Category] SARS, 진단, [키워드] administration airway analysed association Asymptomatic atraumatic biodistribution cardiovascular systems Cell consequence cynomolgus macaque cynomolgus macaques Disrupted exhibit exhibited hamster Host host susceptibility hosts identify Infection Infectious virus intranasal Lower respiratory tract lung Lung pathology methodology Microscopy Mild molecular morphology New World NHP non-human primate organelle outcome outcomes Pathogenesis pathological outcome pathology pathophysiological Post-infection Replication representing SARS-CoV-2 SARS-COV-2 infection susceptible ultrastructure Virological virus virus particle [DOI] 10.1038/s41598-022-23339-x PMC 바로가기
Intranasal nanoemulsion adjuvanted S-2P vaccine demonstrates protection in hamsters and induces systemic, cell-mediated and mucosal immunity in miceArticle Published on 2022-11-022022-11-15 Journal: PLoS ONE [Category] SARS, 변종, 진단, [키워드] Activation Arm cellular COVID-19 disease demonstrated development disease Efficacy hamster humoral IgA immune Immunity immunization induce intramuscular intramuscularly intranasal intranasally Lower respiratory tract lung Lung pathology medical need memory B cell mice mucosal mucosal immune pandemic promote protective immunity public health rapid progress response resulting robust S-2P Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine Seroconversion Spike protein systemic immune response the SARS-CoV-2 Transmission unique upper respiratory tract Vaccine vaccine candidate variants viral clearance weight loss while [DOI] 10.1371/journal.pone.0272594 PMC 바로가기
Efficacy of ensitrelvir against SARS-CoV-2 in a delayed-treatment mouse modelArticle Published on 2022-10-282022-11-15 Journal: Journal of Antimicrobial Chemotherapy [Category] COVID19(2023년), SARS, 진단, 치료제, [키워드] acute respiratory syndrome Administered age anti-SARS-CoV-2 Antiviral Antiviral compound antiviral efficacy body weight Body weight loss caused Cell clinical development coronavirus coronavirus disease correlated COVID-19 demonstrated development dose dose-dependent manner effective Efficacy evaluated expression general treatment Health in vivo increased survival Inflammatory Intervention lung Lung inflammation Lung pathology mice mouse-adapted SARS-CoV-2 nucleocapsid protein pandemic patients with COVID-19 Post-infection protease pulmonary lesion quantified reduced reduced viral load RNA RT-qPCR Safe SARS-CoV-2 SARS-COV-2 infection Support suppressed survival target the SARS-CoV-2 titre treat Treatment Viral RNA was used were infected [DOI] 10.1093/jac/dkac257 PMC 바로가기
Immunological and Pathological Peculiarity of Severe Acute Respiratory Syndrome Coronavirus 2 Beta VariantArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, [키워드] Activation acute respiratory syndrome analysis Beta Beta variant blockade cascade cause CCL2 Characteristics Comparative analysis coronavirus coronavirus 2 COVID-19 COVID-19 pandemic CXCR2 cytokine cytokine release death Disease progression early stage evidenced IL-1β immunological induce Infection Inflammatory cytokine investigated K18-hACE2 late stage Lung pathology mice molecular mechanism Mortality neutrophil recruitment outbreak pathological pathological condition pathology phenotype presymptomatic provide reduced respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis SARS-CoV-2 variant secreted cytokine Strains the SARS-CoV-2 Transcriptome transcriptomes Transmissibility Treatment variant Variant. viral infection weight loss [DOI] 10.1128/spectrum.02371-22 PMC 바로가기
Reliability and clinical correlations of semi-quantitative lung ultrasound on BLUE points in COVID-19 mechanically ventilated patients: The ‘BLUE-LUSS’-A feasibility clinical studyArticle Published on 2022-10-142022-11-16 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 치료기술, [키워드] clinical study correlated correlation COVID-19 COVID-19 pandemic Critically ill Critically ill patient critically ill patients diagnostic feasibility ICUs independent indicated information intensive care intensive care unit Intervention lung Lung pathology mechanically ventilated P/F P/F ratio positive reduce Region reliability risk of infection RT-PCR SARS-CoV2 semi-quantitative significantly single-center the patient Treatment university Variability ventilated patient was performed were recorded [DOI] 10.1371/journal.pone.0276213 PMC 바로가기
Efficacy of COVID-HIGIV in animal models of SARS-CoV-2 infectionArticle Published on 2022-10-102022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 비임상, 진단, [키워드] acute respiratory syndrome animal model anti-SARS-CoV-2 baseline Body weight loss caused China controls convalescent plasma coronavirus COVID-19 COVID-19 vaccines deaths Efficacy evaluated faster hamster hamsters Hospitalization Human Immunoglobulin intravenous Lung inflammation Lung pathology Lungs mice monoclonal antibody mouse model ongoing trial PBS plasma reduced SARS-CoV-2 SARS-COV-2 infection significantly Spread Support therapeutic option treated Treatment Viral load virus was reduced worldwide pandemic [DOI] 10.1038/s41598-022-21223-2 PMC 바로가기
Protection against SARS-CoV-2 transmission by a parenteral prime-Intranasal boost vaccine strategyArticle Published on 2022-10-012022-11-15 Journal: EBioMedicine [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] Administered airway boost Booster vaccine CAF®01 cationic clearance effective elicit elicited European evaluated HexaPro highlight Horizon IgA response immune response intranasal intranasal vaccine lower airway Lung pathology mucosal mucosal immune Neutralizing antibodies onward transmission Parenteral PROTECT protection regimen Research response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 transmission SARS-CoV-2. Serum neutralizing antibody severe disease spike supported Transmission trimer union upper airway upper airways upper respiratory tract Vaccine virus virus transmission [DOI] 10.1016/j.ebiom.2022.104248 PMC 바로가기
Prophylactic treatment of Glycyrrhiza glabra mitigates COVID-19 pathology through inhibition of pro-inflammatory cytokines in the hamster model and NETosisArticle Published on 2022-09-272022-11-16 Journal: Frontiers in Immunology [Category] SARS, 변종, [키워드] accompanied acute respiratory distress addition Comorbidity coronavirus disease COVID-19 COVID-19 pathology cytokine production decrease dysregulated immune response effective Efficacy Evidence functions glycyrrhiza Glycyrrhiza glabra Hamster model hamsters hypercoagulable IL-17A IL-4 immunocompromised individuals immunomodulator immunomodulatory properties Inflammatory cytokine ingredient Lung pathology lung viral load mice mice and human neutrophil functions. mitigate Mortality mRNA expression murine NET NETosis neutrophil polymorphonuclear neutrophil pro-inflammatory cytokine Protective provide Pulmonary pathology reduced reducing robust ROS SARS-CoV-2 SARS-COV-2 infection skewed suppress syndrome Th17 Th2 Th2/Th17 differentiation Treatment vaccination Vaccine variant [DOI] 10.3389/fimmu.2022.945583 PMC 바로가기